HGM2002 Poster Abstracts: 11. Genome Diversity
POSTER NO: 542
Study of Korean Male Origins
Sunghee Hong, Seong-Gene Lee, Yongsook Yoon, Kyuyoung Song
Population studies of genetic markers such as HLA variation and mitochondrial DNA have been used to understand human origins, demographic and migration history. Recently, diversity on the nonrecombining portion of the Y chromosome (NRY) has been applied to the study of human history. Since NRY is passed from father to son without recombination, polymorphisms in this region are valuable for investigating male-mediated gene flow and for complementing maternally based studies of mtDNA. Haplotypes constructed from Y-chromosome markers were used to trace the paternal origins of Korean. By using 38 Y chromosome single nucleotide polymorphism markers, we analyzed the genetic structure of 195 Korean males. The Korean males were characterized by a diverse set of 4 haplogroups (Groups IV, V, VII, X) and 14 haplotypes that were also present in Chinese. The most frequent haplogroup in Korean was Group VII (82.6%). It was also the most frequent haplogroup in Chinese (95%) as well as in Japanese (45%). The frequencies of the haplogroups V, IV, and X were 15.4%, 1%, and 1%, respectively. The second most frequent haplogroup V in Korean was not present in Chinese, but its frequency was similar in Japanese. We have tried to correlate the Y variation with surname to determine how well the clan membership corresponds to Y variation. There were 37 surnames in our sample but genetic variation structure did not correlate with surnames.
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