POSTER NO: 532

Polymorphism of MAOA gene associated with neuropsychiatric diseases at Finno-Ugric populations (Khanty and Komi) of Western Siberia

¹O.V. Andreenkov, ¹T.E. Skvortsova, ¹A.V. Kulikov, ¹L.P. Osipova, ²E.K. Khusnutdinova
¹Institute of Cytology and Genetics of SB RAS, Lavrentyev ave. 10, Novosibirsk, Russia, ²Institute of Biochemistry and Genetics of USC RAS, October ave., Ufa, Russia

Monoamine oxidase (MAO) is a critical enzyme in the degradative deamination of biogenic amines, including the neurotransmitters dopamine and serotonin. Two biochemically distinct forms of the enzyme, A and B, are encoded in separate genes on the human X chromosome. In this study we investigated the polymorphisms of two loci for MAOA among unrelated individuals from the Finno-Ugric populations of Yamal-Nentsi Autonomous district. The presence of restriction-enzyme sites for EcoRV and Fsp4HI was elucidated on PCR fragments derived from genomic DNA. The comparative analysis of genotype frequency distribution of both loci between Khanty and Komi has revealed authentic distinctions (p<0.01) submitted in the Table 1.

Table 1. Distribution of allele (+,-) frequencies for two
MAOA gene (EcoRV and Fsp4HI restriction sites) at Khanty and
Komi of Western Siberia. 

Locus
                Allele Frequency
        N       +       -       N        +      -
                Khanty                   Komi
EcoRV  57      0.56    0.44    60       0.36   0.64
Fsp4HI 57      0.53    0.47    62       0.38   0.62

The existence of interpopulation differences in the frequencies of alleles of MAOA gene permitted the conclusion that this polymorphism can be used as an informative genetic marker for examination of the genetic relationships between Western Siberian populations. Besides, the data received provide a means to evaluate the role of the MAOA gene in various neurologic and psychiatric diseases in which it has been implicated, including Parkinson disease, alcoholism, suicides, schizophrenia, and maniac-depressive illness. Some of those are actual in the High North.