HGM2002 Poster Abstracts: 7. Medical Genomics
POSTER NO: 298
Studying mode of action of natural products through chemical genomics
With the advance in understanding human genome, studying mode of action of natural products through global gene expression profiling has become more opportunistic in drug discovery. ShenZhen Chipscreen Biosciences Ltd. is the leading biopharmaceutical company in China and devoted to discovering new drug from natural products. Our chemical genomic approach including gene expression profiling and chemical profiling provided fast and comprehensive ways to evaluate natural products and compositions from Traditional Chinese Medicine (TCM). We prepared cDNA microarray slides containing human 7427 sequence-verified named genes and established global gene expression of several TCM extract in human cell lines. Gene expression profiles of two cell lines treated with PROSTAT allowed us to classify the mode of action and identify the compound-specific gene expression pattern related with its pharmacological action. Bioinformatic analysis of the expression pattern provided us with a tool to guide the purification steps leading to new chemical entities with the expected pharmacological action.
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